Database : HANSEN Search on : ESTUDOS PROSPECTIVOS [Subject descriptor] References found : 18 [refine] Displaying: 1 .. 18   in format [Detailed]

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Id: 17282 Author: Singh, Navjeevan; Malik, Abha; Arora, Vinod K; Bhatia, Arati Title: Fine needle aspiration cytology of leprous neuritis ..- Source: s.l; s.n; 2003. 5 p. ilus, tab. Abstract: OBJECTIVE: To document the cytomorphologic features of leprous neuritis and their correlation with bacterial density. STUDY DESIGN: A partly retrospective, partly prospective study of the fine needle aspiration cytology of enlarged nerves in leprosy. Cytomorphologic features of nerve aspirates from 28 patients were studied. May-Grünwald-Geimsa and Ziehl-Neelsen staining methods were employed. RESULTS: Five cytomorphologic patterns were observed in smears of nerve aspirates in 19 group I patients with concurrent skin and nerve lesions: (1) inflammation composed of epithelioid cell granulomas (5), bacillary index (BI) = 0; (2) epithelioid cell granulomas with necrosis (5), BI = 0-1+; (3) acellular necrosis (5), BI = 0-4+; (4) macrophage granuloma (3), BI = 5-6+; and (5) granulation tissue (1), BI = 1+. In 9 group II patients with pure neuritic leprosy, 3 patterns were seen: (1) epithelioid cell granulomas (5), BI 0-6+; (2) epithelioid granulomas with necrosis (1), BI = 0; and (3) acellular necrosis (3), BI = 0-6+. CONCLUSION: The entire spectrum of leprosy is seen in nerve aspirates. Necrosis is often a prominent feature. Recognition of the range of cytomorphologic patterns and their correlation with BI contribute to accurate calibration of the disease in nerves, resulting in appropriate choice of treatment. (AU). Descriptors: Granuloma/MI/PA Hanseníase Tuberculóide/CO/*PA Mycobacterium leprae/IP/PY/PH Neurite/MI/*PA Nervos Periféricos/MI/*PA Estudos Prospectivos Estudos Retrospectivos Limits: Adolescente Adulto Criança Feminino Humano Masculino Meia-Idade Location: BR191.1; 09181/s

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Id: 13949 Author: Keita, S; Faye, O; Konare, H. -D; Sow, S. -O; Ndiaye, H. -T; Traore, I Title: Evaluation de la classification clinique des nouveaux cas de lèpre. Etude réalisée à l'Institut Marchoux (Bamako, Mali) Evaluation of the clinical classification of new cases of leprosy. Study conducted at the Marchoux Institute in Bamako, Mali- Source: s.l; s.n; 2003. 3 p. tab. Abstract: INTRODUCTION: The difficulties related to the bacilloscopic diagnosis of leprosy, providing a more reliable classification of cases, in 1995 led the WHO to recommend the use of a new classification, in endemic countries, based on clinical criteria alone, in order to simplify the poly-chemotherapeutic regimens. According to our experience in the Marchoux Institute, this classification may lead to errors in diagnosis through overzealous or mis-interpretation of the two forms of leprosy. The aim of our study was to evaluate the concordance between this clinical classification and that based on a bacilloscopic examination. PATIENTS AND METHODS: We conducted a descriptive study of new cases of leprosy seen at the Marchoux Institute, without distinction in gender or age, from January to December 2000. All the patients included underwent clinical examination and a bacilloscopic exploration to provide a double classification. The concordance between the two classifications was assessed using the Kappa test.RESULTS: Two hundred new cases of leprosy were included. Out of 126 clinically multi-bacillary cases, 61 were confirmed bacteriologically, and 65 were false positives. Out of 74 clinical cases with few bacilli, 2 were bacteriologically multi-bacilli. The concordance between the two classifications was average (Kappa=0.40). There was a significant difference between the percentages of multi-bacilli observed in both classifications (p<10(-8)). DISCUSSION: The clinical classification may well overestimate the multi-bacillary form. In the absence of a reliable bacilloscopic apparatus, a more detailed clinical classification of leprosy forms must be developed. (AU). Descriptors: HANSENIASE/clas HANSENIASE/diag HANSENIASE/patol REACOES FALSO-POSITIVAS ERROS DE DIAGNOSTICO ESTUDOS PROSPECTIVOS DIRETRIZES PARA A PRATICA CLINICA ORGANIZACAO MUNDIAL DA SAUDE Limits: HUMANO MASCULINO FEMININO PRÉ-ESCOLAR CRIANÇA ADOLESCENCIA ADULTO MEIA-IDADE IDOSO IDOSO DE 80 ANOS OU MAIS RESUMO EM INGLES Electronic Medium: http://www.ilsl.br Location: BR191.1; 09090/s

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Id: 13721 Author: Yende, Sachin; Wunderink, Richard Title: Validity of scoring systems to predict risk of prolonged mechanical ventilation after coronary artery bypass graft surgery ..- Source: s.l; s.n; 2002. 6 p. tab, graf. Abstract: STUDY OBJECTIVE: Two scoring systems, (the Spivack scoring system [SSS] and the cardiac risk score [CRS]), have been proposed to predict the risk of prolonged mechanical ventilation (PMV) after coronary artery bypass graft surgery (CABG). The primary objective of this study was to validate the efficacy of these scoring systems to predict the risk of PMV. DESIGN: Prospective observational study. SETTING: Cardiovascular surgical ICU. PATIENTS: Three hundred forty-eight patients underwent CABG. Following surgery, patients were extubated by a standardized respiratory weaning protocol. MEASUREMENTS AND RESULTS: Forty-nine percent of patients had SSS > 0 and had significantly longer duration of mechanical ventilation. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the SSS for failure to extubate at 48 h are 80, 49, 9 per cent, and 98 per cent, respectively. Two hundred thirty-two patients (67.5 per cent), 101 patients (29 per cent), and 12 patients (3.5 per cent) had a CRS of 0 to 4, 5 to 8, and > 8, respectively. Patients with lower scores had shorter duration of mechanical ventilation. The sensitivity, specificity, PPV, and NPV of the CRS for failure to extubate at 10 h are 42, 73, 47 per cent and 69 per cent, respectively. CONCLUSION: The SSS may be used as a preoperative screening tool. A simple questionnaire that includes history of unstable angina, diabetes, congestive heart failure, and smoking prior to hospital admission can be used to calculate the SSS. Patients with SSS < further without surgery to proceed can and PMV for risk low at are 0>. (AU). Descriptors: PONTE DE ARTERIA CORONARIA/* CUIDADOS CRITICOS/* MORTALIDADE HOSPITALAR TEMPO DE INTERNACAO MODELOS LINEARES PERIODO POS-OPERATORIO VALOR PREDITIVO DOS TESTES ESTUDOS PROSPECTIVOS CURVA ROC RESPIRACAO ARTIFICIAL/* DESMAME DO RESPIRADOR Limits: FEMININO HUMANO MASCULINO MEIA-IDADE SUPPORT, NON-U.S. GOV'T Location: BR191.1; 09064/s

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Id: 13665 Author: Khan, Tajamul; Awan, Abdul Aziz; Kazmi, Hasan Sajid; Shah, Ashfaq Ali; Muhammad, Sardar; Muhammad Shad Title: Frequency of ocular complications of leprosy in institutionalized patients in NWFP Pakistan ..- Source: s.l; s.n; 2002. 5 p. ilus, tab, graf. Abstract: BACKGROUND: There is no systemic disease, which so frequently gives rise to disorders of the eye as leprosy does. The study was conducted to determine the prevalence and gravity of ocular complications in institutionalized leprosy patients in NWFP. It is important to provide necessary information to leprosy health workers and general physicians in order to sensitize them to early detection and treatment or referral to appropriate centre. METHODS: A prospective study of ocular complications of leprosy patients was conducted at the leprosy centre of Lady Reading Hospital Peshawar and the Leprosy Hospital Balakot, district Mansehra. The study included a record of the name, age, sex, type, duration of disease and completion of multi-drug therapy (MDT). Classification of the patients was done according to Ridley and Jopling 5-group system. Visual acuity was tested by Snellen chart and those patients having a vision of less than 3/60 were labelled as blind. Ocular adnexa were examined by naked eye and lacrimal sac regurgitation test was done. Slit lamp biomicroscopy was done for anterior segment examination and direct ophthalmoscope was used for fundoscopy. RESULTS: The authors studied 143 patients in the above mentioned leprosy centres. Out of these, 59 had lepromatous leprosy, 39 borderline tuberculoid leprosy, 9 tuberculoid leprosy, 33 borderline lepromatous leprosy, and 33 borderline leprosy. The majority of patients came from the northern districts of NWFP, including Malakand division and district Mansehra. The male to female ratio was 4:1. The age of the patients ranged from 14 to 80 years and the duration of the disease ranged from 1 year to 48 years. Ocular complications were found in 73 per cent of the patients. These complications included loss of eyebrows in 57 patients, loss of eyelashes in 37, corneal changes (including opacity, ulceration, and/or anaesthesia) in 44, iridocyclitis in 31, lagophthalmos in 36, ectropion in 13, and chronic dacryocystitis in 3. Of the total of 15 (11 per cent) patients who went blind from ocular complications, 16 eyes did so due to corneal opacities, 6 eyes due to cataract, 5 eyes due to chronic anterior uveitis and one eye due to corneal ulcer, panophthalmitis and phthisis bulbi each. CONCLUSIONS: A significant number of leprosy patients (73 per cent) have ocular complications. The frequency of ocular complications increases with the increasing age and duration of disease of the patients. (AU). Descriptors: HANSENIASE/compl PAQUISTAO/epidemiol ESTUDOS PROSPECTIVOS OFTALMOPATIAS/etiol - DISTRIBUICAO POR IDADE Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO ADOLESCENTE IDOSO DE 80 ANOS OU MAIS Electronic Medium: http://www.ilsl.br Location: BR191.1; 09118/s

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Id: 13622 Author: Hegazy, Aly A; Abdel-Hamid, Ibrahim A; Ahmed, El-Shahat F; Hammad, Sabry M; Hawas, Samia A Title: Leprosy in a high-prevalence Egyptian village: epidemiology and risk factors ..- Source: s.l; s.n; 2002. 6 p. ilus, tab. Abstract: BACKGROUND: The epidemiology of leprosy in rural Egypt is unknown. This prospective household survey was conducted in a high-prevalence Egyptian village in order to explore the epidemiologic characteristics of the disease and to determine the possible socioeconomic and HLA genotype risk factors. METHODS: The subjects of the study were the residents of Kafr-Tambul village in the Dakahlia governorate, Egypt. There were 10,503 inhabitants of the village, of whom 9643 (91.8 per cent) had a complete visual skin examination, and suspected leprosy patients were subjected to histopathological examination and slit skin smears. Each household was interviewed to record personal data on family members, family size, education, occupation, crowding index at sleep, social score and source of water supply. Human leukocyte antigen (HLA) class II genotypes were analyzed in all leprosy patients and in a number of both household (N = 124) and non-household (N = 30) contacts. RESULTS: The overall prevalence of clinical leprosy in the village studied was 24.9/10,000 (95 per cent CI = 16.3-37.6). Individuals above the age of 40 years were 4 times more likely to develop leprosy (OR = 4, P= 0.01). The degree of education, crowding index at sleep, social score and source of water supply were found to be unlikely to increase the risk of leprosy (P > 0.05). The frequencies of HLA-DR2 and -DQ1 were significantly associated with leprosy (OR = 3.33 and 5.4; CI = 0.95-12.07 and 1.08-30.19, respectively, all P < 0.05). CONCLUSIONS: Our study provides the first picture of the epidemiology of leprosy in a high-prevalence village in rural Egypt. Leprosy detection campaigns should be initiated and directed towards high-prevalence villages. Provision of leprosy control activities in rural health units is necessary in order to detect new cases. The risk for leprosy is associated with HLA-DR2 and -DQ1 markers, and these markers appear to increase personal susceptibility to leprosy in this village. (AU). Descriptors: FATORES ETARIOS EGITO/epidemiol PREDISPOSICAO GENETICA PARA DOENÇA/genet GENOTIPO ANTIGENOS HLA/genet LEVANTAMENTOS EPIDEMIOLOGICOS HANSENIASE/epidemiol HANSENIASE/etiol HANSENIASE/genet PREVALÊNCIA ESTUDOS PROSPECTIVOS FATORES DE RISCO POPULACAO RURAL/estatíst FATORES SOCIOECONÔMICOS Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09012/s

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Id: 13362 Author: Rao, P. T; Jena, S. K Title: Surgical treatment of plantar ulcers in leprosy ..- Source: s.l; s.n; 1986. 4 p. tab. Abstract: Plantar ulcers present a serious problem in the management of leprosy. After studying the mechanism of ulceration and the causes of their indolence, it appears that the treatment of the disease by antileprotic drugs is not sufficient. The underlying causes, such as anaesthesia, bony deformities and paralysis, should usually be treated by surgical means. Anaesthesia can be reversed by decompression of the posterior tibial nerve if this is done early. Deformities should be corrected by procedures on the soft tissues or bones, and chronic infection eradicated to prevent recurrence of the ulceration. A combination of procedures may sometimes be needed.(AU). Descriptors: DOENCAS DO PE/etiol DOENCAS DO PE/cirurg HANSENIASE/compl METODOS ESTUDOS PROSPECTIVOS RECIDIVA ULCERA CUTÂNEA/etiol ULCERA CUTÂNEA/cirurg Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01917/s

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Id: 12239 Author: Keita, S; Tiendrebeogo, A; Konare, H; Cisse, B.-S; Faye, O Title: Nouveaux cas de lèpre à L'Institut Marchoux (Bamako, Mali): Etude comparative 1988-1997 New cases of leprosy at the Marchoux Institute: a comparative study 1988-1997- Source: s.l; s.n; 2001. 3 p. tab. Descriptors: CRIANÇA ESTUDOS TRANSVERSAIS HANSENIASE MALI ESTUDOS RETROSPECTIVOS ESTUDOS PROSPECTIVOS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08641/s

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Id: 11715 Author: Malik, R; Martin, P; Wigney, D; Swan, D; Sattler, P. S; Cibilic, D; Allen, J; Mitchell, D. H; Chen, S. C. A; Hughes, M. S; Love, D. N Title: Treatment of canine leproid granuloma syndrome: preliminary findings in seven dogs ..- Source: s.l; s.n; 2001. 7 p. ilus, tab. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA CLARITROMICINA DOENÇAS DO CAO DOENÇAS DO CAO CAES ESQUEMA DE MEDICAÇAO QUIMIOTERAPIA COMBINADA LEPROSTATICOS ESTUDOS PROSPECTIVOS ESTUDOS RETROSPECTIVOS RIFAMPINA SINDROME Limits: RELATO DE CASO ANIMAL CAES FEMININO MASCULINO Location: BR191.1; 07358/s

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Id: 11649 Author: Mvogo, Côme Ebana; Hiag-Bella, Assumpta Luciene; Ellong, Augustin; Achu, Joko Henry; Nikeng, Protest Fonguazi Title: Ocular complications of leprosy in Cameroon ..- Source: s.l; s.n; 2001. 3 p. tab. Descriptors: HANSENIASE HANSENIASE CAMAROES DOENÇAS DA CORNEA DOENÇAS DA CORNEA INFECÇOES OCULARES BACTERIANAS INFECÇOES OCULARES BACTERIANAS DOENÇAS PALPEBRAIS DOENÇAS PALPEBRAIS ESTUDOS PROSPECTIVOS UVEITE ANTERIOR UVEITE ANTERIOR ACUIDADE VISUAL Location: BR191.1; 08426/s

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Id: 11499 Author: Grimaud, Jérônime; Verchot, Béatrice; Blum, Laurent; Chapuis, Françõis; Millan, Jacques Title: Clinical screening for ulnar nerve damage in leprosy patients ..- Source: s.l; s.n; 2000. 2 p. ilus, tab. Descriptors: HANSENIASE EXAME NEUROLOGICO ESTUDOS PROSPECTIVOS TATO Location: BR191.1; 08389/s

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Id: 10223 Author: Miko, Tivadar L; Le Maitre, Connie; Kinfu, Yamrot Title: Damage and regeneration of peripheral nerves in advanced treat leprosy ..- Source: s.l; s.n; 1993. 5 p. ilus, tab. Descriptors: FIBROSE PERNA HANSENIASE HANSENIASE HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE REGENERAÇAO NERVOSA NERVOS PERIFÉRICOS NERVOS PERIFÉRICOS ESTUDOS PROSPECTIVOS Location: BR191.1; 06924/s

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Id: 10193 Author: Sehgal, Virendra N; Chaudhry, Anup K Title: Leprosy in children: a prospective study ..- Source: s.l; s.n; 1993. 4 p. tab, graf. Descriptors: HANSENIASE HANSENIASE PREVALENCIA ESTUDOS PROSPECTIVOS Location: BR191.1; 07106/s

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Id: 10042 Author: Srinivasan, S; Nehru, V. I; Mann, S. B. S; Sharma, V. K; Bapuraj, J. R; Das, A Title: Study of ethmoid sinus involvement in multibacillary leprosy ..- Source: s.l; s.n; 1998. 4 p. ilus, tab, graf. Descriptors: HANSENIASE HANSENIASE HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA BIOPSIA ENDOSCOPIA SEIO ETMOIDE SEIO ETMOIDE ESTUDOS PROSPECTIVOS TOMOGRAFIA COMPUTADORIZADA POR RAIOS X Location: BR191.1; 07007/s

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Id: 9942 Author: Hatta, Mochammed; Izumi, Shinzo; Klatser, Paul R Title: Evaluation of the Mycobacterium leprae particle agglutination (MLPA) test as a tool in the epidemiology of leprosy in high prevalence village in South Sulawesi, Indonesia ..- Source: s.l; s.n; 1995. 5 p. tab. Descriptors: HANSENIASE HANSENIASE HANSENIASE ANTICORPOS ANTIBACTÉRIAS IGM TRIAGEM DE MASSA MYCOBACTERIUM LEPRAE PREVALENCIA ESTUDOS PROSPECTIVOS SAUDE SUBURBANA Location: BR191.1; 06849/s

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Id: 9812 Author: Hieselaar, Laetitia C. J. M; Hogeweg, Margreet; De Vries, Christina L Title: Corneal sensitivity in patients with leprosy and in controls ..- Source: s.l; s.n; 1995. 3 p. tab. Descriptors: HANSENIASE DOENÇAS DA CORNEA INFECÇOES OCULARES BACTERIANAS MUSCULOS OCULOMOTORES ESTUDOS PROSPECTIVOS Location: BR191.1; 06736/s

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Id: 9738 Author: Grimaud, J; Chapuis, F; Millan, J Title: Les vitesses de conduction motrices cubitales etagees dans la maladie de Hansen ..- Source: s.l; s.n; 1994. 5 p. tab. Descriptors: HANSENIASE HANSENIASE HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE ELETROMIOGRAFIA CONDUÇAO NERVOSA DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO DOENÇAS DO SISTEMA NERVOSO PERIFÉRICO ESTUDOS PROSPECTIVOS NERVO ULNAR Limits: HUMANO Location: BR191.1; 06711/s

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Id: 9452 Author: Chopra, N. K; Lakhani, J. D; Pande, R. S; Modi, K. B; Pasle, R. K Title: Renal involvemente in leprosy ..- Source: s.l; s.n; 1991. 3 p. ilus, tab. Descriptors: BIOPSIA POR AGULHA PAISES EM DESENVOLVIMENTO INDIA RIM HANSENIASE HANSENIASE DIMORFA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE NEFRITE ESTUDOS PROSPECTIVOS Location: BR191.1; 06308/s

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Id: 9251 Author: Gonzales, Regina Senefonte Title: Contribuicao ao estudo da evolucao clinica, baciloscopica e histopatologica, de doentes de hanseniase multibacilar, submetidos a dois periodos diferentes de multidrogaterapia ?- Source: Sao Paulo; s.n; 1996. 106 p. ilus, tab. Thesis: Present for Universidade de Sao Paulo. Faculdade de Medicina presented for the degree Mestre. Abstract: A partir de 1993, o Ministerio da Saude, de acordo com as orientacoes da Organizacao Mundial da Saude (OMS), passou a orientar que o tratamento de doentes de hanseniase multibacilar, deveria ser feito com multidrogaterapia (MDT) de duracao fixa de 24 meses. Neste estudo, foram analisados, retrospectivamente, o estado clinico, baciloscopico e histopatologico de 52 doentes de hanseniase multibacilar, tratados com MDT. Estes doentes foram divididos em dois grupos, de acordo com o tempo de tratamento: grupo A, tratados por 24 meses (em media por 25,72 meses) e grupo B, tratados por mais de 24 meses (em media 47,66 meses). Os criterios para a alta dos doentes do grupo A foram as recomendacoes da OMS e para os doentes do grupo B, foram; involucao clinica das lesoes cutanes(AU). Descriptors: HANSENIASE HANSENIASE QUIMIOTERAPIA COMBINADA MYCOBACTERIUM LEPRAE FATORES DE TEMPO ESTUDOS PROSPECTIVOS Location: BR191.1; WC335.102, G589c

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